Connect with us

Hi, what are you looking for?

NewsTimes.co.uk

HEALTH

Decline in trials for Alzheimer’s disease

More than 99% of drug trials for Alzheimer’s disease during the past decade have failed, according to a study.

There is an urgent need to increase the number of potential therapies being investigated, say US scientists.

Only one new medicine has been approved since 2004, they report in the journal Alzheimer’s Research & Therapy.

The drug failure rate is troubling and higher than for other diseases such as cancer, says Alzheimer’s Research UK.

Dr Jeffrey Cummings, of the Cleveland Clinic Lou Ruvo Center for Brain Health, in Las Vegas, and colleagues, examined a public website that records clinical trials.

Between 2002 and 2012, they found 99.6% of trials of drugs aimed at preventing, curing or improving the symptoms of Alzheimer’s had failed or been discontinued.

This compares with a failure rate of 81% for cancer drugs.

The failure rate was “especially troubling” given the rising numbers of people with dementia, said Dr Simon Ridley, of Alzheimer’s Research UK.

Advertisement. Scroll to continue reading.

“The authors of the study highlight a worrying decline in the number of clinical trials for Alzheimer’s treatments in more recent years,” he said.

“There is a danger that the high failure rates of trials in the past will discourage pharmaceutical companies from investing in dementia research.

“The only way we will successfully defeat dementia is to continue with high quality, innovative research, improve links with industry and increase investment in clinical trials.”

Experimental models

Dr Eric Hill, of the School of Life and Health Sciences at Aston University, said more research was needed to understand the complex mechanisms behind the disease.

“The development of better experimental models that could be incorporated into a battery of tests, will not only help us to understand the changes that occur in the brains of Alzheimer’s disease patients, but also provide tools for the development of new drug treatments that could slow or stop the onset of disease,” he told BBC News.

Alzheimer’s disease is the most common form of dementia.

It affects more than 820,000 people in the UK and costs the economy £23bn a year.

 

Advertisement. Scroll to continue reading.

Source: BBC

You May Also Like

UK NEWS

Read more about switzerland women here. Swiss ladies and men are not reknown for being the most chatty, outgoing or spontaneous when meeting strangers...

FOOD TIPS

In food, if there is one thing you can say without fear of contradiction, it is this: Britain loves burgers. The UK market is...

UK NEWS

Professing to be the lead in Thai relationship with over 1.5 million enrolled single people, Cupid Media’s ThaiCupid brings the one in every of...

WORLD NEWS

An exclusive article form Orestis Karipis In the 1930’s and 1940’s acid was the weapon of deceived husbands and wives in the Western world...

Copyright © 2020 NewsTimes.co.uk All Rights Reserved